Scholar Profile

Joseph C. Sun

Assistant Professor
Immunology Program
Memorial Sloan-Kettering Cancer Center
408 East 69th Street, ZRC-1402
New York, NY 10065
Voice: 646-888-3228
Personal Homepage
2011 Searle Scholar

Research Interests

Regulation of Natural Killer Cells and their Roles in Prevention of Viral Infections and Cancer

The immune system responds to viral infections by introducing a complex interplay of immune cells and factors, whose goal is to eliminate the intruding pathogen. One such effector cell in the antiviral response is the Natural Killer (NK) cell, which secretes inflammatory cytokines and directly kills infected cells. The focus of our research is aimed at defining the signals that NK cells require to mount an effective immune response against pathogens. We are also exploring the regulatory mechanisms keeping NK cells in check, thereby safeguarding against potential autoimmunity. Understanding the biology of NK cells and how these cells of the immune system specifically attack virally infected and transformed cells, but not healthy cells, we will be able to develop more effective preventative and therapeutic approaches in the battle against infectious diseases and cancer.