Department of Pharmaceutical Chemistry
University of California, San Francisco
UCSF Mission Bay Campus1700 4th St., MC 2532San Francisco, CA 94158
2010 Searle Scholar
Cellular processes are often carried out by coordinated participation of many proteins. To understand how them work together, we are developing super-resolution microscopy and single-molecule imaging methods and using them to study the following problems:
(1) proteins organization in large complexes such as the nuclear pore complex and centrosome,
(2) dynamic protein interaction in regulating G-protein coupled receptor signaling,
(3) cell adhesion molecules in controlling the development of the nervous system, and,
(4) protein-DNA interactions in the nucleus.
We are also interested in combining synthetic chemistry, protein engineering and microfluidics-based high-throughput screening to create new fluorescent probes that allow us to better study these cellular structures and processes.
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