Seth B. Herzon
Department of Chemistry
155 Whitney Avenue, Suite 214New Haven, CT 06520
2010 Searle Scholar
Synthetic Methods Development and Natural Product Synthesis
Research in the Herzon group encompasses the disciplines of natural products synthesis and synthetic methods development. In the former area, we are working to develop efficient, flexible syntheses of complex natural products. Our synthetic routes will present challenges to the capabilities of the field and, in the search for solutions, force an extension of its current boundaries. A prudent, thoughtful approach to target selection is undertaken so that the success of these investigations may potentially serve a broader cause as well. For example, our efforts may provide synthetic material for the study and treatment of human diseases, or alternatively, facilitate investigation of the structure and function of otherwise inaccessible molecules. Thus, the syntheses we develop may be incorporated into larger interdisciplinary programs, however a passion for complex molecule synthesis is what drives us and this forms the core of our program.
In the area of synthetic methods, we seek to identify and reduce to practice essential transformations that are currently not feasible, or only of limited scope. In searching for solutions to these problems we will make use of any tools available to us. Thus, our investigations might lead us to explore the chemistry of novel organic and inorganic reagents, and organometallic complexes, and will be complemented by mechanistic studies, where appropriate. The primary goal of these investigations is the development of practical synthetic methods of broad utility.
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