Department of Biochemistry and Cell Biology
6100 Main Street, MS-140Houston, TX 77005
2009 Searle Scholar
Genetic Interaction Map of Development Genes
Our research goal is to decipher the gene networks behind complex traits such as development and behavior. We apply a suite of technologies in genetics, computer science, and engineering in our approach. We are interested in both developing new technologies for genetic studies and applying these tools to conduct large-scale genetic screens in the nematode C. elegans.
Hypothesis-driven research is a process of two steps: hypothesis generation and experimental verification. We develop high-throughput tools for both steps. Specifically, we are building a bioinformatic system that predicts genetic interaction networks, and a computer vision system that facilitates high-speed experimental testing of C. elegans genetic interactions.
How does a genome specify the properties of an organism? With the systems biology approach, we expect to bring new insights into the classical quest in genetics for underlying mechanisms of genome function.
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