Frederick W. Alt
Investigator, Howard Hughes Medical Institute, The Children's Hospital of Boston
Senior Investigator, CBR Institute for Biomedical Research
Harvard University Medical School
1983 Searle Scholar
Molecular Mechanisms Involved with the Differentiation of Lymphocytes.A particular focus is the mechanism and control of the genomic rearrangement processes involved with antigen receptor variable region gene assembly and immunoglobulin heavy chain class-switching. They have recently identified gene products that function both in the context of double strand DNA break repair and antigen receptor variable region gene assembly. For their studies, they use a combination of molecular and cellular methods in combination with transgenic and chimeric animal approaches. During the past years they have created numerous lines of mutant and transgenic mice including immunodeficient mice that cannot assemble antigen receptor genes and mice deficient in expression of various transcription factors, nuclear oncogenes and signaling molecules.
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