Susan K. Dutcher
Professor and Interim Head
Department of Genetics, Cell Biology and Physiology
St. Louis, MO 63110
1984 Searle Scholar
Functions of Microtubules and Centrosomes In our laboratory we use the unicellular green alga, Chlamydomonas, to study the function of the centrosome and microtubules in cell organization and cell division.
In our study of centrosomes, we are interested in three questions.
2. What is the role of the centrosome in establishing cellular and flagellar asymmetry? We are addressing this question using mutant strains that have lost the normal handedness or asymmetry of the flagella. These strains were isolated because they are not able to swim toward a light source; they are phototactic defective because they have lost the inherent asymmetry of the flagella. In addition, we are examining mutant strains that assembly only one flagellum rather than two.
3. What is the role of the centrosome in progression through the cell cycle? We are isolating genes for proteins that are found in the centrosome of other organisms with the goal of using reverse genetics to look at the function of these genes. These include g-tubulin and centrin.
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