Orion D. Weiner
Department of Biochemistry
University of California, San Francisco
600 16th Street
S474, Weiner Lab, MC 2240
San Francisco, CA 94158-2517
2007 Searle Scholar
How Cells Establish Polarity and Guide Movement
Many eukaryotic cells have the capacity to polarize and migrate in response to external gradients of chemoattractant. Directed motility is essential for single-celled organisms to hunt and mate, axons to find their way in the developing nervous system, and cells in the innate immune system to find and kill invading pathogens. We are only beginning to understand the circuitry of the internal 'compass' used by eukaryotic cells to regulate polarity during chemotaxis. Our research focuses on identifying key missing components of the cellular compass and determining how the overall signaling network is wired together to coordinate the many activities involved in directed cell polarity. Our model systems for these studies are neutrophils (one of nature's master migratory cells) and neutrophil lysates, which contain very high concentrations of many proteins that regulate polarity.
Figure 1. Human neutrophil
(from my finger) polarizing in response to gradient of
We are developing techniques to deconstruct and reconstitute key polarity circuits in vitro and spatially manipulate and monitor signaling in vivo in our quest to understand how these amazing migratory cells work. This knowledge is essential if we are to ultimately control inflammation, cancer metastasis, and other processes that depend on properly guided cell movement.
Named Scientist Magazine, Top 10 innovations of 2009 and Science Signaling Magazine 2009: Signaling Breakthroughs of the Year
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