James E. Ferrell
Department of Molecular Pharmacology
Stanford, CA 94305-5332
1991 Searle Scholar
My research focuses on the web of protein kinases that regulates the entry of cells into the cell cycle and the progress of cells from one phase of the cell cycle to another. The biological system my laboratory most often uses is the Xenopus laevis oocyte, which offers a wealth of technical advantages for studies of cell cycle transitions.
There are two main projects underway in my laboratory:
1. MAP kinase regulation and biological function.
My laboratory group is examining the mechanism and significance of MAP kinase activation and translocation, through a combination of biochemical, molecular biological, and genetic approaches: 1)Activation of Cdc2 by MAP kinase; 2)Regulation of MK phosphatase; 3)Interaction of MAP kinase and Rsk; and 4)Dynamics of the MAP kinase cascade.
2. NimA/Xnek1 and the G2-M transition.
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