Department of Chemistry and
Department of Molecular Biosciences
3613 Silverman Hall
Evanston, IL 60208
2000 Searle Scholar
Professor Kelleher is a bioanalytical chemist and is interested in finding novel posttranslational modifications and studying enzymatic mechanisms of large enzymes (>500 kDa). Using high-resolution mass spectrometry to spearhead the research, we correlate protein fragmentation data to fully sequenced genomes to scan for chemically-altered gene products and the cellular alteration machinery. Also, the biosynthesis of many clinically-used drugs occurs on ultralarge enzymes acting as solid supports for covalent catalysis, ideal for study by mass spectrometry.
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